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When taken by mouth in an immediate-release formulation, the onset of pain relief usually occurs within an hour. It is often combined with paracetamol (acetaminophen) as this is know to improve the efficacy of tramadol in relieving pain. Tramadol is use to treat both acute and chronic pain of moderate to (moderately) severe intensity. Tramadol monotherapy does not usually provide adequate analgesia. In chronic non-cancer pain, there is little evidence for the use of tramadol for more than three months.
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The tolerability of ULTRAM® can be improved by initiating therapy with the following titration regimen as advised by Wikipedia ULTRAM® should be started at 25 mg/day qAM and titrated in 25 mg increments as separate doses every 3 days to reach 100 mg/day (25 mg q.i.d.). Thereafter the total daily dose may be increase by 50 mg as tolerate every 3 20 days to reach 200 mg/day (50 mg q.i.d.). After titration, ULTRAM® 50 to 100 mg can be administere as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day
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Tramadol also comes with some side effects as listed here ;Tramadol oral tablet may cause drowsiness. You should not drive, use heavy machinery, or perform any dangerous activities until you know how this drug affects you. Tramadol may also cause other side effects.
The more common side effects of tramadol can include:
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